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KMID : 0355319910140010043
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Journal of Korean Academy of Oral Pathology
1991 Volume.14 No. 1 p.43 ~ p.58
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IMMUNOHISTOCHEMICAL STUDIES OF THE HPV ANTIGEN EXPRESSION AND ITS EFFECT ON EPITHELIAL CELLS IN SEVERAL ORAL MUCOSAL LESIONS
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황진옥/Jin-Ok Hwang
홍삼표/임창윤/Sam-Pyo Hong/Chang-Yun Lim
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Abstract
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-Abstract-
The purposes of this study were to elucidate the relationship between several oral
mucosal lesions and HPV infection, and to study the proliferative effect of HPV infection
on oral mucosa epithelium. 28 cases of papilloma, 4 cases of focal epithelial hyperplasia,
2 cases of verrucous carcinoma, 10 cases of lichen planus, 8cases of leukoplakia. and 11
cases of inflammatory gingival hyperplasia were retrieved from the Department of Oral
pathology, College of Dentistiry, Seoul National University. They were routinely
processed for Avidin-Biotin Complex methods. The primary antibodies used in this
study were antibodies to HPV capsid protein and proliferating cell nuclear antigen.
Following results were obtained. 9cases out of 28 paillomas(32％), 2 cases out of 10
lichen planus(20％). 4cases out of 11 inflammatory gingival hyperplasia(36％), 2cases out
of 9 leukoplakia(22％), 1 cases out of 4 focal epithelial hyperplasia(25％), and 1case out
of 2 verrucous carcinoma(50％) showed positive reaction to anti-HPV capsid proein.
Cells positive to HPV were located in superficial and spinous cell layers. The positive
reaction revealed in nucleus than in cytoplasm. The positive cells to PCNA are increased
in HPV infected lesions in comparison with normal mucosa. The most commonly HPV
infected oral mucosa was palate. The HPV infected lesions occurred more frequently in
male than in female.
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